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Santo Domingo de Guzmán is a city in the Dominican Republic. The city is the capital of the country. The city lies at Caribbean Sea, at the mouth of the Ozama River. The river flows 148 kilometers before emptying into the Caribbean Sea. Santo Domingo position with its banks was of great importance to the city's economic development and growth of trade during colonial times. Ozama River is the country's busiest port.

The city was founded as Santo Domingo de Guzmán between 1496 and 1498, by Bartolomeo Columbus (Bartolomé Colón), brother of Christopher Columbus. It was originally on the eastern banks of the Ozama, but was moved to the west shore by a hurricane that destroyed the city in 1502.

In the city listed to the first citadel, the first hospital (Hospital de San Nicolás de Bari), the first cathedral (Catedral de Santo Domingo), and the first monastery (Monasterio de San Francisco) in the Western Hemisphere.

In 1538 began the construction of the oldest university in the "New World." It was named Santo Tomás de Aquino by St. Thomas Aquinas, and exists today as the Universidad Autónoma de Santo Domingo (UASD).

Average temperature in Santo Domingo vary slightly, because the tropical trade winds help to reduce heat and humidity throughout the year. But the temperature is almost never below 25 degrees.

Many of Santo Domingo's most famous landmarks are within the Zona Colonial district of the city, a UNESCO World Heritage Site since 1990. The Colonial Zone, bordered by the Río Ozama, also has an impressive collection of 16th century buildings, including palatial houses and majestic churches that reflect the architectural style of the late Middle Ages. A number of Santo Domingo museums, is also in the Zona Colonial district.

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